Bioinformatician Position at Phagos
The Bioinformatics Team at Phagos is looking for a Bioinformatics Engineer to lead and scale their high-throughput structural genomics capabilities. In this role, the candidate will design and implement automated bioinformatics pipelines that analyze protein–protein and protein–ligand interactions at scale, moving beyond sequence identity to structure-based clustering and protein–protein coupling.
The bioinformatician will play a critical role in enabling data-driven predictions of phage host range and resistance, directly supporting the development of next-generation phage therapies.
Key Responsibilities:
- Design, build, and maintain robust bioinformatics pipelines using Nextflow
- Automate structural prediction and clustering across thousands of phage and bacterial genomes
- Implement, benchmark, and optimize structure-based clustering algorithms
- Organize phage receptor-binding proteins (RBPs) and bacterial membrane proteins into functional families
- Scale and benchmark state-of-the-art structural prediction tools
- Develop modules to detect and classify non-protein bacterial surface markers, specifically lipopolysaccharides (LPS)
- Build logic and statistical models linking RBP structural clusters with bacterial surface profiles
- Predict phage host range, resistance mechanisms, and automate protein docking workflows.
Skills Required
- Hands-on experience with protein structure prediction and clustering tools such as AlphaFold, ESMFold, Foldseek, and TM-align
- Experience automating docking workflows (e.g., HADDOCK, Chai-1)
- Strong scripting skills for biological and structural data analysis using Biopython, Pandas, and Bio.PDB.
- Proven experience building and scaling bioinformatics pipelines.
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