Protein Therapeutics Researcher in Antibody Discovery & Phage Display at IBRI
The Indiana Biosciences Research Institute (IBRI), Indianapolis, is seeking a Protein Therapeutics Researcher to support early-stage drug discovery programs through recombinant protein production, antibody characterization, and phage display-based antibody discovery. This role contributes to target validation, hit identification, and lead optimization for therapeutic development.
The Indiana Biosciences Research Institute is a translational research institute connecting academia, biotech startups, and industry partners to accelerate drug discovery. Research programs span areas such as Alzheimer’s disease, metabolic disorders, and rare diseases, with a focus on bringing next-generation therapies to patients.
Key Responsibilities
This role requires the candidate to:
- Develop and optimize protein expression systems (bacterial, insect, and mammalian).
- Purify recombinant proteins using affinity, ion-exchange, and size-exclusion chromatography.
- Perform molecular biology techniques including DNA cloning, mutagenesis, and plasmid analysis.
- Maintain mammalian and insect cell cultures for protein production.
- Support phage display antibody discovery campaigns and analyze antibody–antigen interactions.
- Document experimental results and collaborate with multidisciplinary research teams.
Qualifications & Skills Required
- Bachelor’s degree in Biology, Biochemistry, Molecular Biology, or related field.
- Experience with protein expression and purification techniques.
- Knowledge of laboratory assays such as SDS-PAGE, Western blot, and protein quantification.
- Experience with AKTA chromatography systems.
- Familiarity with BSL-2 cell culture techniques.
- Knowledge of phage display or antibody characterization methods.
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