{"id":8319,"date":"2025-02-12T08:54:15","date_gmt":"2025-02-12T08:54:15","guid":{"rendered":"https:\/\/jobs.thephage.xyz\/?p=8319"},"modified":"2025-12-02T10:51:42","modified_gmt":"2025-12-02T10:51:42","slug":"secret-weapons-or-molecular-junk-determining-the-influence-of-bacteriophages-in-enterococcal-infections","status":"publish","type":"job","link":"https:\/\/thephage.xyz\/jobs\/jobs\/secret-weapons-or-molecular-junk-determining-the-influence-of-bacteriophages-in-enterococcal-infections\/","title":{"rendered":"Secret weapons or molecular junk? Determining the influence of bacteriophages in enterococcal infections"},"content":{"rendered":"\n

E. faecalis<\/em>\u00a0and\u00a0E. faecium<\/em>, commonly found as part of the healthy gut flora in humans and animals, have become significant opportunistic pathogens in recent years. These bacteria are responsible for a variety of infections, including endocarditis and urinary tract, wound, and bloodstream infections, and are commonly associated with the hospital environment. Owing to increasing rates of resistance to last-resort antibiotics, phage therapy \u2014 using bacteriophages to treat bacterial infections \u2014 has been suggested as a potential solution for multidrug-resistant enterococcal infections.<\/p>\n\n\n\n

Seeking a highly motivated PhD student to join a multidisciplinary project aimed at identifying bacteriophage-associated factors that contribute to bacterial fitness, virulence, and evolution in the globally important species\u00a0Enterococcus faecalis<\/em>\u00a0and\u00a0Enterococcus faecium<\/em>. Though enterococci are ranked as priority pathogens by the World Health Organisation and phage therapy is actively being considered for these increasingly hard-to-treat infections, our knowledge about the roles that prophages play in\u00a0i)\u00a0<\/em>the ability of their host bacteria to cause infections,\u00a0ii)<\/em>\u00a0their ability to interfere with phage therapy interventions, and\u00a0iii)\u00a0<\/em>what unintended side effects phage therapy might induce, is very limited.<\/p>\n\n\n\n

The successful candidate will receive training in a diverse range of techniques, including sequence analyses, comparative genomics and protein family evolution; microbiology; biochemistry, and molecular biology, including the use of CRISPR-based systems for targeted mutagenesis. <\/p>\n\n\n\n

Applicants should send an up-to-date CV and cover letter to\u00a0suzie.humphrey@strath.ac.uk<\/a><\/strong><\/p>\n\n\n\n

Register your interest here https:\/\/www.findaphd.com\/phds\/project\/secret-weapons-or-molecular-junk-determining-the-influence-of-bacteriophages-in-enterococcal-infections\/?p182348<\/a><\/strong><\/p>\n\n\n\n

For more phage-related research and job opportunities, click here https:\/\/jobs.thephage.xyz\/<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

E. faecalis\u00a0and\u00a0E. faecium, commonly found as part of the healthy gut flora in humans and animals, have become significant opportunistic pathogens in recent years. These bacteria are responsible for a variety of infections, including endocarditis and urinary tract, wound, and bloodstream infections, and are commonly associated with the hospital environment. Owing to increasing rates of […]<\/p>\n","protected":false},"author":5,"featured_media":8320,"template":"","job_type":[],"job_discipline":[],"job_location":[449],"class_list":["post-8319","job","type-job","status-publish","has-post-thumbnail","hentry","job_location-uk"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t