A Marsden-funded research programme investigates the molecular mechanisms by which a new phage-derived enzyme (an endolysin) interacts with and crosses Gram-negative bacterial membranes. Utilize biophysical, structural, and computational tools to elucidate these interactions and engineer novel antimicrobial enzymes.<\/p>\n\n\n\n
The Biomolecular Interaction Centre, University of Canterbury, seeks applicants with a PhD in biochemistry, structural biology, molecular biology, or a related field. The candidate is \u00a0expected to have strong experience in protein expression, purification, and characterisation, familiarity with membrane protein biophysics, liposome assays, or NMR spectroscopy.<\/p>\n\n\n\n
The candidate should have experience with molecular dynamics simulations or computational modelling phage biology, clinical microbiology or antimicrobial protein design o Interest in translational research and antimicrobial resistance. The candidate will have access to world-class facilities (NMR, crystallography, microbiology, and computational biology) located at UC, PHF Science, and University of Auckland.<\/p>\n\n\n\n