. As predicted, clinical reports of antibiotic resistance followed, such as the evolution of resistant in early clinical trials for streptomycin efficacy in treating tuberculosis. Nevertheless, the discovery and development of novel antibiotics flourished for many decades. However, in the latter 20th century, antibiotic discovery slowed, and the alarming increase in rates of antibiotic resistance signaled that the golden age of antibiotics had perhaps
ended. Indeed, aside from three new antibiotic classes discovered between 2005 and 2018, no novel drug classes have been developed since the 1980s, this approach has also been selected for broader resistance mechanisms, such as extended-spectrum beta-lactamases, adaptive changes that are perhaps more easily evolved compared to de novo resistance mechanisms.
Phage Therapy: A Renewed Approach
Animal Models for Efficacy
Krestownikowa, W., & Gubin, W. (1925). Die Verteilung and die Ausscheidung von Bak-teriophagen im Meerschweinchen-organismus bei subkutaner Applicationsart. J. Microbiol., Patolog. i. Infekzionnich bolesney, 1, 3.
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