|Loughlin et, 2020|
Jumbo phages are bacteriophages (phages) with genetic information (genomes) larger than 200 kilobases. These phages are known as “jumbo” because they have a huge genome size. In addition, they exhibit several novel characteristics not seen in smaller genome phages, which distinguish jumbo phages in aspects of genome and virion structure, progeny propagation, and evolution. According to some studies, jumbo phages can be useful in various ways in this era of antibiotic resistance. They have proven to be more effective than other phages, particularly when dealing with bacterial defense systems and infectivity.
- Yuan Y, Gao M. Jumbo Bacteriophages: An Overview. Front Microbiol. 2017 Mar 14;8:403. DOI: 10.3389/fmicb.2017.00403. PMID: 28352259; PMCID: PMC5348500.
- Laughlin, T.G., Deep, A., Prichard, A.M., et al. Architecture and self-assembly of the jumbo bacteriophage nuclear shell. Nature 608, 429–435 (2022). https://doi.org/10.1038/s41586-022-05013-4