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The lab of Jeremy Chase Crawford in the Department of Host-Microbe Interactions is seeking a highly skilled Sr. Scientist to develop and implement novel technical approaches for assaying single cell dynamics, high throughput functional screening, and high parameter molecular phenotyping. This position will work at the cross-section of immunology, molecular methods development, and integrative analytics […]
This project will investigate how AMR plasmids, bacterial defenses, and antibiotic treatment interact to determine the overall spread of AMR plasmids. To do this, you will study the transmission dynamics of clinically relevant AMR plasmids in E. coli populations. To defend themselves against their parasites, bacteria carry a wide range of defense systems. Recent work […]
Looking for an enthusiastic and experienced research technician to join the Therapeutic Vulnerabilities in Solid Tumors and Sarcoma group of Dr Sophie Postel-Vinay and the Chromosomal Translocations group of Prof Terry Rabbitts. The exciting program is part of a new Fight Kids Cancer grant. It aims to develop and evaluate novel therapeutic approaches to target aggressive transcription […]
A major limitation of phage therapy is the typically very narrow host ranges of phages that are isolated from nature. This means that novel phages need to be found in nature for essentially every clinical case that one aims to treat in this manner. The project involved deals with the engineering of bacteriophages to enlarge […]
Colibacillosis is one of the most common and important diseases in poultry production often linked to extra-intestinal colonization of avian pathogenic Escherichia coli (APEC). APEC infection can impact on the overall performance of birds leading to decreased body weight, carcass yield, meat quality, and increased mortality. Colibacillosis in poultry husbandry is also a major health concern […]
The ongoing antimicrobial resistance crisis has incentivised research into alternative antibacterial and antibiofilm agents. One of them is cold plasma and plasma-activated water (PAW), which is produced by exposing water to a cold plasma discharge. This process generates a diverse array of reactive oxygen and nitrogen species (ROS/RNS) with antimicrobial properties. In this study, we […]
The emergence of powerful artificial intelligence (AI) tools, now supports complex prediction and generation tasks at molecular, systems, and genomic levels. In this project, AI will be harnessed to study the bacterial-phage relationship by training it on publicly available phage and bacterial genome datasets, alongside large empirical bacteria-phage infection matrices, to enable an AI-guided synthetic genomics approach for […]
C. difficile is intrinsically resistant to many antibiotics and thrives in the disrupted gut environment created by antibiotic treatment. C. difficile is a spore-forming bacteria – able to form metabolically dormant endospores resistant to harsh environments – and phage infection. Evolutionary theory suggests that sporulation may have dramatic impacts on bacteria-phage dynamics, potentially driving unexpected […]
The relationship between bacteriophage and virome diversity and plant response to rising temperatures is largely unexplored. Microbial communities are crucial for plant health, enhancing plant tolerance to stresses, including pathogens, by boosting defense responses. Elevated temperatures could alter leaf/root chemistry, impacting microbial diversity and diminishing the capacity to suppress pathogens. Bacterial genus Xanthomonas causes diseases in over […]
Examples of common E. coli bacterial diseases include colibacillosis in chickens and swine caused by avian pathogenic E. coli (APEC) and enterotoxigenic E. coli (ETEC), respectively; Shiga toxin-producing E. coli (STEC) colonization of cattle with implications for the human food chain and urinary system; uropathogenic E. coli (UPEC) and bloodstream infections in all hosts, often […]
