Browse all currently listed roles.
This project will experimentally test whether clinical isolates from non-tuberculous mycobacterial infections collected from pulmonary sources, such as those acquired during biopsy or bronchiolar wash, from sputum, or from other sampled tissues contain evidence of bacteriophage(s). Based on Oxford Nanopore sequencing performed in-lab, the student will perform genomic sequence analysis of the clinical isolates for […]
Mobile Genetic Elements (MGEs), such as temperate bacteriophages and conjugative plasmids, which can transfer horizontally and vertically between bacterial cells, are known to play a crucial role in shaping the composition and behaviour of microbial communities. In this project, using synthetic engineering, bioinformatics, bioimaging and experimental infection assays to investigate the molecular interactions between temperate […]
In this project, the student will investigate the use of bacteriophages, viruses of bacteria, as biocontrol agents to act against Listeria present in the food production chain. The project will focus on phage discovery, characterisation and phage-host interactions linked with bacterial and phage genomics. In this funded project at the Quadram Institute Bioscience in the […]
Cystic fibrosis is the most common, genetically inherited disease in the UK and there are over 11,000 people living with this in the UK. Maintaining lung health throughout the life-course is a key priority for people with cystic fibrosis (pwCF). Lung infections are a major cause of morbidity and mortality in pwCF. Bacteriophage (phage) therapy […]
Test the binding efficiency of phage proteins to bacteria present in food samples and optimise the capture of bacteria from food samples using magnetic nanoparticles in a microfluidic device. Conduct assays using an optofluidic device to detect bacteria in food samples. The Piteira Group is dedicated to bring advanced Nanoeletronics, into mainstream applications within the […]
In this project, the student will carry out large-scale infection assays with diverse S. aureus isolates and phages to identify which phages are the most effective inhibitors of S. aureus growth, and find out why this is the case. Mobile genetic elements (MGEs), such as phages and plasmids, play a key role in AMR dissemination […]
The aim of this work is to investigate the role of E. meningoseptica phages in its biology as opportunistic human pathogen. in this project work to determine the impacts of phages infecting this pathogenic bacterial species with a focus on phage infection dynamics to assess how phages contribute to its increasing pathogenic success. This represents an opportunity […]
Apply and develop new genetic screenings (based on CRISPRi) to characterize phage genes that influence clinical efficacy against bacterial pathogens, characterizing them in their molecular context using interaction proteomics (affinity purification, proximity labeling, co-fractionation mass spectrometry) and engineered “superphages” that show increased efficacy against clinical isolates. The Fossati lab investigates the composition and mechanism of […]
Work on Phage Transduction powered by Diversity Generating Retroelements in an Experimental study and biotechnological tool development by Pasteur-Paris University. click here for the list of projects https://www.nature.com/naturecareers/job/12829187/pasteur-paris-university-international-doctoral-program-ppu-/ Apply here https://ppu.pasteur.fr/ppu_etud_accueil.aspx For more phage-related opportunities, click here https://jobs.thephage.xyz/
In the complex interplay between bacteriophages and their bacterial hosts, anti-phage defense mechanisms, such as the recently discovered Zorya system, play a crucial role. “New concepts in prokaryotic virus-host interactions,” aims to investigate fundamental immune mechanisms of bacteria against bacteriophages through a combination of live-cell microscopy, biochemistry, and bacterial genetics. The Humboldt-Universität zu Berlin is […]
